When you stay here, you're staying at one of the closest hotels near Ameristar Casino St Louis and a great pick of hotels near Lindenwood University. But that's not all. Hollywood Casino is just across the river. Additionally, there's the history on display at the Lewis and Clark Boathouse, the many wineries where you can enjoy a few sips and nearly endless dining and nightlife options. Downtown St Louis is only a half-hour away by car, and everything to do and see in that city is easy to reach and enjoy when you stay affordably and comfortably with us at Comfort Suites St Charles-St Louis.